GHRH analog stimulating pituitary growth hormone release for anti-aging protocols.
TL;DR — Sermorelin is a growth hormone peptide with a typical starting dose of 300 µg. For a 5 mg vial, add 2 mL bacteriostatic water to yield 2500 µg/mL.
Add 2 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 2500 µg/mL.
What is the recommended dose of Sermorelin?
A typical research dose is 300 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Sermorelin vial?
A 5 mg vial reconstituted with 2 mL BAC water yields approximately 16 doses at 300 µg each.
Peptide Intelligence
What is the half-life of Sermorelin?
Sermorelin has a very short half-life of under 10 minutes due to rapid plasma degradation by endopeptidases. Daily subcutaneous injection (typically pre-sleep) is the standard research protocol. Its short half-life limits GH elevation to a brief pulsatile burst.
How does Sermorelin compare to Tesamorelin?
Both are GHRH analogs, but Tesamorelin has a longer half-life (~26 min) and is FDA-approved for HIV lipodystrophy. Sermorelin is the original GHRH fragment (1-29) and was previously FDA-approved for pediatric GH deficiency. Tesamorelin is considered more stable in solution.
Is Sermorelin typically used alone or in combination?
Sermorelin is often combined with Ipamorelin or GHRP-2 to amplify GH release. The combination of a GHRH analog with a ghrelin mimetic acts synergistically on the pituitary. Some protocols use Sermorelin alone at bedtime for anti-aging purposes.