CJC-1295 + Ipamorelin: The GHRH/GHRP Stack Explained

CJC-1295 (No DAC / mod GRF 1-29) is a GHRH analog - it binds GHRH receptors in the pituitary and directly stimulates GH synthesis and release. Ipamorelin is a GHRP (ghrelin receptor agonist) - it binds ghrelin receptors independently, triggering a separate signaling cascade that also promotes GH secretion.

The synergy is not additive - it is multiplicative. A landmark study by Khorram et al. demonstrated that combined GHRH + GHRP administration produced GH pulses 5-10× larger than either compound alone at equivalent doses. This occurs because the two pathways converge on somatotroph cells via different second messengers (cAMP for GHRH, PKC/IP3 for ghrelin), amplifying the net secretory signal beyond what either receptor class can achieve independently.

Endogenous GH secretion is pulsatile - the largest pulse occurs approximately 60-90 minutes after sleep onset, driven by delta-wave sleep activation of hypothalamic GHRH neurons. Pre-sleep injection of the CJC-1295 + Ipamorelin stack amplifies this natural pulse rather than creating an off-cycle pulse at a random time of day.

CJC-1295 (No DAC) has an in vivo half-life of ~30 minutes, meaning it clears before the next natural pulse if dosed more than 2-3 hours earlier. The protocol of injecting 30-45 minutes before sleep onset is specifically designed to have peak plasma concentrations coincide with the onset of the natural nocturnal GH pulse - producing the largest measurable GH spike within the research protocol window.

CJC-1295 No DAC: 5mg vial + 2mL BAC water = 2.5mg/mL (2,500 mcg/mL). A 100 mcg dose = 0.04mL = 4 units. A 300 mcg dose = 0.12mL = 12 units. Both are readable on a U-100 syringe with a 0.3mL barrel - use a 0.3mL syringe, not a 1mL, to make 4-unit reads accurate.

Ipamorelin: 5mg vial + 2.5mL BAC water = 2mg/mL (2,000 mcg/mL). A 200 mcg dose = 0.1mL = 10 units. A 300 mcg dose = 0.15mL = 15 units. Again, clean reads on a 0.3mL barrel. The most common error is using a 1mL syringe - each graduation is 10 units on a 100-unit syringe, so a 4-unit draw for CJC-1295 becomes essentially unreadable.