⚖ Head-to-Head · Mitochondrial Peptides

Humanin vs SS-31

Mechanism, half-life, dosing & research status compared side-by-side.

Humanin
Mitochondrial & Longevity
Not Approved
MitochondrialLongevityAnti-agingAging
Humanin is a 21-amino acid mitochondrial-derived peptide (MDP) encoded within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome - the same mitochondrial gene region that encodes MOTS-c. Discovered in 2001 …
Full Humanin profile →
SS-31
Mitochondrial
Phase II/III
MitochondrialLongevityCardiacEnergy
SS-31 (Elamipretide) is a synthetic aromatic-cationic tetrapeptide that selectively concentrates in the inner mitochondrial membrane (IMM) due to its unique charge properties. It is the most advanced mitochondrial-target…
Full SS-31 profile →
Technical Specs Comparison
MetricHumaninSS-31
Research Status Extensively Studied Extensively Studied
Molecular Weight ~2,687 Da 638.8 Da
Half-Life ~2–4 hours ~2–4 hours
Peak Time ~1 hour ~30–60 min
Typical Dose 2–10 mg 1–5 mg
Frequency Once daily or 3× weekly Once daily
Route Subcutaneous Subcutaneous
Amino Acids 21 4
WADA Status Not Listed Not Listed
FDA Status Not Approved Phase II/III
Stack Compatibility & Key Differences
Humanin and SS-31 are commonly stacked - rated synergistic in research protocols.
PK Plotter
Visualize SS-31 plasma levels → Plot →
Frequently Asked Questions
What is the difference between Humanin and SS-31?
Humanin: Humanin is a 21-amino acid mitochondrial-derived peptide (MDP) encoded within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome - the same mitochondrial gene region that encodes MOTS-c. Discovered in 2001 … SS-31: SS-31 (Elamipretide) is a synthetic aromatic-cationic tetrapeptide that selectively concentrates in the inner mitochondrial membrane (IMM) due to its unique charge properties. It is the most advanced mitochondrial-target…
Can you stack Humanin and SS-31?
Humanin and SS-31 are commonly stacked - rated synergistic in research protocols.
Which has a longer half-life, Humanin or SS-31?
Humanin half-life: ~2–4 hours. SS-31 half-life: ~2–4 hours.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-15.
● Peer-reviewed sources ● Audit timestamp: 2026-06-15 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Humanin profile · SS-31 profile · All comparisons
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