Add 2 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 2.5 mg/mL.
What is the recommended dose of Humanin?
A typical research dose is 2 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Humanin vial?
A 5 mg vial reconstituted with 2 mL BAC water yields approximately 2 doses at 2 mg each.
Peptide Intelligence
What is Humanin and where does it originate?
Humanin is a 21-amino acid peptide encoded within the 16S rRNA gene of the mitochondrial genome, making it a mitochondria-derived peptide similar to MOTS-C. Its circulating levels decline with age and correlate inversely with insulin resistance and neurodegeneration.
What are the primary cytoprotective mechanisms of Humanin?
Humanin acts via a trimeric cytokine receptor complex and a formyl peptide receptor. It inhibits mitochondrial apoptosis pathways, protects neurons against amyloid-beta toxicity, improves insulin sensitivity, and reduces vascular inflammation.
What is the half-life of Humanin?
Humanin has a short plasma half-life of approximately 30–60 minutes, necessitating daily subcutaneous injection. Humanin-S14G (HNG) is a modified analog with approximately 1000-fold greater potency, often used at lower doses in research protocols.