Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5 mg/mL.
What is the recommended dose of MOTS-C?
A typical research dose is 10 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a MOTS-C vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 1 doses at 10 mg each.
Peptide Intelligence
What is MOTS-C and where does it come from?
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome's 12S rRNA gene. It is the first mitochondria-derived peptide shown to have systemic regulatory effects, acting as a mitokine communicating metabolic stress to peripheral tissues.
What metabolic effects does MOTS-C produce?
MOTS-C activates AMPK, improves insulin sensitivity, enhances glucose uptake in skeletal muscle, and reduces lipid accumulation. In rodent studies it prevents diet-induced obesity and metabolic syndrome. Circulating MOTS-C levels decline with age, making it a longevity research target.
What is the half-life of MOTS-C?
MOTS-C has a relatively short plasma half-life estimated at a few hours, necessitating daily or multiple-times-weekly subcutaneous injections in research protocols. Exercise is known to naturally increase endogenous MOTS-C secretion, which partially explains exercise's metabolic benefits.