Add 2 mL of bacteriostatic water to a 50 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 25 mg/mL.
What is the recommended dose of SS-31?
A typical research dose is 10 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a SS-31 vial?
A 50 mg vial reconstituted with 2 mL BAC water yields approximately 5 doses at 10 mg each.
Peptide Intelligence
What is SS-31 and how does it work?
SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) is a mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane by binding cardiolipin. It prevents cytochrome c release, reduces ROS production, and restores mitochondrial cristae architecture in damaged cells.
What is the half-life of SS-31?
SS-31 has a plasma half-life of approximately 2–3 hours after subcutaneous injection, but its tissue half-life in mitochondria-rich tissues such as heart, kidney, and brain may be significantly longer. Daily subcutaneous injections are used in most research protocols.
What diseases is SS-31 being clinically researched for?
Clinical trials have studied SS-31/Elamipretide for Barth syndrome, heart failure, dry age-related macular degeneration, primary mitochondrial myopathy, and renal ischemia-reperfusion injury. Multiple Phase 2 trials have demonstrated safety and preliminary efficacy signals.