⚖ Head-to-Head · GHRP vs GHRH Standalone

Ipamorelin vs Sermorelin

Mechanism, half-life, dosing & research status compared side-by-side.

Ipamorelin
Growth Hormone
Not Approved
Growth HormoneRecoveryBody CompositionAnti-aging
Ipamorelin is a synthetic pentapeptide growth hormone releasing peptide (GHRP) that selectively stimulates GH secretion from pituitary somatotrophs. Unlike other GHRPs (GHRP-2, GHRP-6, Hexarelin), Ipamorelin does not sig…
Full Ipamorelin profile →
Sermorelin
Growth Hormone
Compounding Only
Growth HormoneAnti-agingRecoverySleep
Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from 1997 until its volu…
Full Sermorelin profile →
Technical Specs Comparison
MetricIpamorelinSermorelin
Research Status Extensively Studied Extensively Studied
Molecular Weight 711.9 Da 3,357.9 Da
Half-Life ~2 hours ~10–20 min
Peak Time ~60 min ~30–60 min
Typical Dose 100–300 µg 200–500 µg
Frequency 1–3× daily Once daily (bedtime)
Route Subcutaneous Subcutaneous
Amino Acids 5 29
WADA Status Prohibited Prohibited
FDA Status Not Approved Compounding Only
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
Visualize Ipamorelin plasma levels → Plot →
Frequently Asked Questions
What is the difference between Ipamorelin and Sermorelin?
Ipamorelin: Ipamorelin is a synthetic pentapeptide growth hormone releasing peptide (GHRP) that selectively stimulates GH secretion from pituitary somatotrophs. Unlike other GHRPs (GHRP-2, GHRP-6, Hexarelin), Ipamorelin does not sig… Sermorelin: Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from 1997 until its volu…
Can you stack Ipamorelin and Sermorelin?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Ipamorelin or Sermorelin?
Ipamorelin half-life: ~2 hours. Sermorelin half-life: ~10–20 min.
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-07-21.
Peer-reviewed sources Audit timestamp: 2026-07-21 Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Ipamorelin profile · Sermorelin profile · All comparisons
Ready to calculate your exact draw volume?
Enter your vial size and BAC water to get precise IU markings for any dose.
Calculate Ipamorelin dose → Calculate Sermorelin dose →