Side-by-Side Comparison · 2026

Ipamorelin vs Sermorelin

Ipamorelin vs Sermorelin — mechanism, half-life, dosing, and research status compared. Which is right for your protocol?

Ipamorelin
Growth Hormone

Ipamorelin is a synthetic 5-amino acid growth hormone releasing peptide (GHRP) that selectively stimulates pituitary GH secretion without raising cortisol, prolactin, or appetite hormones. Acts on ghrelin receptors (GHSR-1a) for clean pulsatile GH release. Phase I/II research sta...

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Sermorelin
Growth Hormone

Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from 1997 until its voluntary market withdrawal in 2008 for commercial reasons - not...

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Key Parameters
Parameter Ipamorelin Sermorelin
Category Growth Hormone Growth Hormone
Research Extensively Studied Extensively Studied
Half-Life ~2 hours ~10–20 min
Typical Dose 100–300 µg 200–500 µg
Frequency 1–3× daily Once daily (bedtime)
Route Subcutaneous Subcutaneous
FDA Status Not Approved Compounding Only

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Frequently Asked Questions
What is the difference between Ipamorelin and Sermorelin?
Ipamorelin: Ipamorelin is a synthetic 5-amino acid growth hormone releasing peptide (GHRP) that selectively stimulates pituitary GH secretion without raising cortisol, prolactin, or appetite hormones. Acts on ghr... Sermorelin: Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH, retaining full biological activity at the GHRH receptor. It was FDA approved (Geref) for GH deficiency in children from...
Which has a longer half-life, Ipamorelin or Sermorelin?
Ipamorelin half-life: ~2 hours. Sermorelin half-life: ~10–20 min.
Can you stack Ipamorelin and Sermorelin?
Ipamorelin and Sermorelin are in the same category and used together in research protocols. Always consult relevant literature and follow appropriate guidelines.

For research use only. Not medical advice. ASCEND does not conduct or endorse any specific research protocol. Always consult relevant scientific literature and regulatory guidelines.