⚖ Head-to-Head · Mitokine vs Pineal

MOTS-c vs Epithalon

Mechanism, half-life, dosing & research status compared side-by-side.

MOTS-c
Mitochondrial & Longevity
Not Approved
MitochondrialLongevityExercise PerformanceEnergy
MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome - making it unique among peptides as a mitochondrial, rather than nuclear, gene product.…
Full MOTS-c profile →
Epithalon
Longevity & Telomere
Not Approved
LongevityTelomereAnti-agingPineal
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Full Epithalon profile →
Technical Specs Comparison
MetricMOTS-cEpithalon
Research Status Extensively Studied Extensively Studied
Molecular Weight 2,174.6 Da 390.3 Da
Half-Life 4 hours ~30 min
Peak Time ~1 hour ~20–30 min
Typical Dose 5–15 mg 5–10 mg
Frequency Daily or 3× per week Once daily × 10–20 days (cycle)
Route Subcutaneous Subcutaneous / IV
Amino Acids 16 4
WADA Status Prohibited Not Listed
FDA Status Not Approved Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter · Visualize plasma levels over time
Plot MOTS-c → Plot Epithalon →
Frequently Asked Questions
What is the difference between MOTS-c and Epithalon?
MOTS-c: MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome - making it unique among peptides as a mitochondrial, rather than nuclear, gene product.… Epithalon: Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Can you stack MOTS-c and Epithalon?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, MOTS-c or Epithalon?
MOTS-c half-life: 4 hours. Epithalon half-life: ~30 min.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-24.
● Peer-reviewed sources ● Audit timestamp: 2026-06-24 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · MOTS-c profile · Epithalon profile · All comparisons
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