Longevity

Epithalon Dosing & Reconstitution Calculator

Telomerase activator peptide for anti-aging and telomere length maintenance.

TL;DR — Epithalon is a longevity peptide with a typical starting dose of 10 mg. For a 50 mg vial, add 2 mL bacteriostatic water to yield 25 mg/mL.
10 mg
Start Dose
50 mg
Vial
2 mL
BAC Water
25
mg/mL
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Frequently Asked
How do I reconstitute Epithalon?
Add 2 mL of bacteriostatic water to a 50 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 25 mg/mL.
What is the recommended dose of Epithalon?
A typical research dose is 10 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Epithalon vial?
A 50 mg vial reconstituted with 2 mL BAC water yields approximately 5 doses at 10 mg each.
Peptide Intelligence
What is the mechanism of Epithalon?
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide that stimulates telomerase activity in somatic cells, potentially increasing telomere length. It also normalizes cortisol and melatonin rhythms and has been shown to extend lifespan in rodent models.
How long does a typical Epithalon cycle last?
Standard research protocols use 10 mg/day via subcutaneous injection for 10–20 consecutive days, 1–2 times per year. This episodic cycling mirrors the approach used in the original Russian clinical research on bioregulator peptides by Khavinson and colleagues.
What evidence exists for Epithalon extending lifespan?
Multiple studies by Khavinson et al. showed Epithalon extended mean and maximum lifespan in mice, fruit flies, and other models. Human clinical data from Russian studies suggests improved health markers in elderly subjects. Telomerase activation is considered the primary proposed mechanism.
Recommended Next Step
Longevity Stack
Thymosin Alpha-1 is frequently paired with Epithalon in longevity protocols for immune restoration alongside telomerase activation.
Open Thymosin Alpha-1 Calculator →
Also Explore
Primary Sources
Khavinson Telomerase Study (2003) Pineal Bioregulator Review (2012)
Data last reviewed 2026-04-19 · Methodology →
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