⚖ Head-to-Head · Triple vs Single Agonist

Retatrutide vs Semaglutide

Mechanism, half-life, dosing & research status compared side-by-side.

Retatrutide
Metabolic / Triple Incretin Agonist
Phase 3 (obesity, T2D); not yet approved
GLP-1 AgonistGIP AgonistGlucagon AgonistWeight ManagementMetabolicPhase 3
Retatrutide is a first-in-class triple receptor agonist developed by Eli Lilly that simultaneously activates GLP-1, GIP, and glucagon receptors. By adding glucagon receptor activity to the dual incretin mechanism of tirz…
Full Retatrutide profile →
Semaglutide
Metabolic / GLP-1 Agonist
Approved (T2D, obesity)
GLP-1 AgonistFDA ApprovedWeight ManagementMetabolicDiabetes
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Full Semaglutide profile →
Technical Specs Comparison
MetricRetatrutideSemaglutide
Research Status Phase 3 Clinical Trials FDA Approved
Molecular Weight ~4.4 kDa 4113.58 Da
Half-Life ~6 days ~168 hours (7 days)
Peak Time 48-96 hours post-injection 1-3 days post-injection
Typical Dose 1-24 mg/week (Phase 2); Phase 3 doses TBD 0.25-2.4 mg/week (SC); 3-14 mg/day (oral)
Frequency Once weekly Once weekly (SC); once daily (oral)
Route Subcutaneous injection Subcutaneous injection; oral tablet
Amino Acids 36 31
WADA Status Not listed Not listed
FDA Status Phase 3 (obesity, T2D); not yet approved Approved (T2D, obesity)
Stack Compatibility & Key Differences
Semaglutide has FDA approval; Retatrutide is research-only.
PK Plotter · Visualize plasma levels over time
Plot Retatrutide → Plot Semaglutide →
Frequently Asked Questions
What is the difference between Retatrutide and Semaglutide?
Retatrutide: Retatrutide is a first-in-class triple receptor agonist developed by Eli Lilly that simultaneously activates GLP-1, GIP, and glucagon receptors. By adding glucagon receptor activity to the dual incretin mechanism of tirz… Semaglutide: Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Can you stack Retatrutide and Semaglutide?
Semaglutide has FDA approval; Retatrutide is research-only.
Which has a longer half-life, Retatrutide or Semaglutide?
Retatrutide half-life: ~6 days. Semaglutide half-life: ~168 hours (7 days).
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-07-21.
● Peer-reviewed sources ● Audit timestamp: 2026-07-21 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Retatrutide profile · Semaglutide profile · All comparisons
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