Metabolic & Weight

Retatrutide Dosing & Reconstitution Calculator

Triple GIP/GLP-1/glucagon receptor agonist. Phase 3 TRIUMPH titration: 0.5 mg up to 12 mg over 24 weeks.

TL;DR - Retatrutide is a metabolic & weight peptide with a typical starting dose of 0.5 mg. For a 10 mg vial, add 2 mL bacteriostatic water to yield 5 mg/mL.
0.5 mg
Start Dose
10 mg
Vial
2 mL
BAC Water
5
mg/mL
0.5 mg draw on a 100-unit insulin syringe
010203040506070809010010 IUascendpeptide.org
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Frequently Asked
How do I reconstitute Retatrutide?
Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5 mg/mL.
What is the recommended dose of Retatrutide?
A typical research dose is 0.5 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Retatrutide vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 20 doses at 0.5 mg each.
How many IU is 0.5 mg of Retatrutide on a syringe?
With a 10 mg vial reconstituted in 2 mL bacteriostatic water, the concentration is 5 mg/mL. For a 0.5 mg dose: Volume = 0.5 mg ÷ 5 mg/mL = 0.1 mL. Draw to the 10 line on a 100-unit insulin syringe. You can adjust these values in the ASCEND calculator for any vial size.
What does a Retatrutide dosage calculator do?
A Retatrutide dosage calculator converts your vial size and BAC water volume into an exact syringe draw in IU. Enter your vial strength (10 mg), reconstitution volume (2 mL), and target dose to get the precise line to draw on an insulin syringe.
What is the Retatrutide reconstitution calculator formula?
Draw volume (mL) = Dose (mg) divided by Concentration (mg/mL). For a 10 mg vial with 2 mL BAC water: concentration = 5 mg/mL. For a 0.5 mg dose, the ASCEND calculator gives the exact IU line on your syringe instantly.
Peptide Intelligence
What is the half-life of Retatrutide?
Retatrutide has a half-life of approximately 6 days, supporting once-weekly subcutaneous dosing. This extended half-life is achieved through fatty acid side-chain technology similar to other long-acting GLP-1 receptor agonists.
How does Retatrutide differ from Tirzepatide?
Retatrutide is a triple agonist targeting GIP, GLP-1, and glucagon receptors, while Tirzepatide is a dual GIP/GLP-1 agonist. The addition of glucagon receptor activity may drive greater energy expenditure and fat oxidation per unit dose.
What are proper storage conditions for Retatrutide?
Store reconstituted Retatrutide at 2–8°C and protect from light. Do not freeze. Lyophilized powder can typically be stored at room temperature for short periods; refrigeration is preferred for long-term stability.
Primary Sources
Phase 2 Trial (NEJM 2023) ClinicalTrials NCT05929066
Data last reviewed 2026-06-03 · Methodology →
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