⚖ Head-to-Head · GLP-1 vs Amylin Analog

Semaglutide vs Cagrilintide

Mechanism, half-life, dosing & research status compared side-by-side.

Semaglutide
Metabolic / GLP-1 Agonist
Approved (T2D, obesity)
GLP-1 AgonistFDA ApprovedWeight ManagementMetabolicDiabetes
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Full Semaglutide profile →
Cagrilintide
Metabolic / Amylin Analog
Phase 3 (obesity); not yet approved
Amylin AnalogWeight ManagementMetabolicPhase 3Combination Therapy
Cagrilintide is a long-acting amylin analog developed by Novo Nordisk that acts on amylin receptors (calcitonin receptor/RAMP complex) in the hypothalamus and brainstem to regulate food intake and body weight. As a compl…
Full Cagrilintide profile →
Technical Specs Comparison
MetricSemaglutideCagrilintide
Research Status FDA Approved Phase 3 Clinical Trials
Molecular Weight 4113.58 Da ~4.1 kDa
Half-Life ~168 hours (7 days) ~7 days
Peak Time 1-3 days post-injection 72-96 hours post-injection
Typical Dose 0.25-2.4 mg/week (SC); 3-14 mg/day (oral) 0.3-4.5 mg/week
Frequency Once weekly (SC); once daily (oral) Once weekly
Route Subcutaneous injection; oral tablet Subcutaneous injection
Amino Acids 31 37
WADA Status Not listed Not listed
FDA Status Approved (T2D, obesity) Phase 3 (obesity); not yet approved
Stack Compatibility & Key Differences
Semaglutide has FDA approval; Cagrilintide is research-only.
PK Plotter
Visualize Semaglutide plasma levels → Plot →
Frequently Asked Questions
What is the difference between Semaglutide and Cagrilintide?
Semaglutide: Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri… Cagrilintide: Cagrilintide is a long-acting amylin analog developed by Novo Nordisk that acts on amylin receptors (calcitonin receptor/RAMP complex) in the hypothalamus and brainstem to regulate food intake and body weight. As a compl…
Can you stack Semaglutide and Cagrilintide?
Semaglutide has FDA approval; Cagrilintide is research-only.
Which has a longer half-life, Semaglutide or Cagrilintide?
Semaglutide half-life: ~168 hours (7 days). Cagrilintide half-life: ~7 days.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-24.
● Peer-reviewed sources ● Audit timestamp: 2026-06-24 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Semaglutide profile · Cagrilintide profile · All comparisons
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