⚖ Head-to-Head · Semax vs N-Acetyl Form

Semax vs N-Acetyl Semax

Mechanism, half-life, dosing & research status compared side-by-side.

Semax
Cognitive & Nootropic
Not Approved
CognitiveNeuroprotectionNootropicBDNF
Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, developed in Russia in the 1980s by the Institute of Molecular Genetics. It is approved as a pharmaceutical drug in Russia for cognitive impairment, is…
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N-Acetyl Semax
Cognitive & Neurological
Not Approved
CognitiveNootropicBDNFIntranasalSemax Analog
N-Acetyl Semax is a modified form of Semax (the Russian-approved nootropic peptide based on ACTH(4-7)) with N-terminal acetylation added for improved enzymatic stability. The acetyl group protects against aminopeptidase …
Full N-Acetyl Semax profile →
Technical Specs Comparison
MetricSemaxN-Acetyl Semax
Research Status Extensively Studied Research Use
Molecular Weight 813.9 Da -
Half-Life ~minutes (plasma); CNS effects 24h+ ~4–6 hours (extended vs. standard Semax)
Peak Time ~30–60 min (intranasal) -
Typical Dose 300–900 µg intranasal 100–400 µg
Frequency Once or twice daily Once or twice daily
Route Intranasal (primary) / Subcutaneous Intranasal
Amino Acids 7 7
WADA Status Not Listed Not Listed
FDA Status Not Approved Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
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Frequently Asked Questions
What is the difference between Semax and N-Acetyl Semax?
Semax: Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, developed in Russia in the 1980s by the Institute of Molecular Genetics. It is approved as a pharmaceutical drug in Russia for cognitive impairment, is… N-Acetyl Semax: N-Acetyl Semax is a modified form of Semax (the Russian-approved nootropic peptide based on ACTH(4-7)) with N-terminal acetylation added for improved enzymatic stability. The acetyl group protects against aminopeptidase …
Can you stack Semax and N-Acetyl Semax?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Semax or N-Acetyl Semax?
Semax half-life: ~minutes (plasma); CNS effects 24h+. N-Acetyl Semax half-life: ~4–6 hours (extended vs. standard Semax).
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-15.
● Peer-reviewed sources ● Audit timestamp: 2026-06-15 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Semax profile · N-Acetyl Semax profile · All comparisons
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