Cognitive

Semax Dosing & Reconstitution Calculator

Nootropic heptapeptide supporting BDNF, focus, memory, and mood.

TL;DR — Semax is a cognitive peptide with a typical starting dose of 500 µg. For a 10 mg vial, add 2 mL bacteriostatic water to yield 5000 µg/mL.
500 µg
Start Dose
10 mg
Vial
2 mL
BAC Water
5000
µg/mL
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Frequently Asked
How do I reconstitute Semax?
Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5000 µg/mL.
What is the recommended dose of Semax?
A typical research dose is 500 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Semax vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 20 doses at 500 µg each.
Peptide Intelligence
What is the mechanism of Semax?
Semax is a synthetic heptapeptide analog of ACTH(4-7). It enhances BDNF and NGF production, increases dopaminergic and serotonergic activity, and modulates the melanocortin system. Primary research applications are cognitive enhancement and neuroprotection.
What is the half-life of Semax?
Semax has a very short plasma half-life of approximately 30–90 minutes due to rapid enzymatic breakdown. Intranasal administration provides more direct CNS delivery. Subcutaneous administration requires more frequent dosing than intranasal routes.
How does Semax compare to N-Acetyl Semax?
N-Acetyl Semax has greater CNS penetration and longer duration of action than standard Semax due to its acetyl modification. Standard Semax is most commonly used intranasally in Russia for stroke recovery. N-Acetyl versions are preferred by many researchers for longer-lasting effects.
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Neuro Stack
Selank (anxiolytic) pairs with Semax (cognitive enhancer) for a balanced neuro stack — Semax boosts BDNF/focus while Selank reduces anxiety.
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Primary Sources
BDNF Upregulation (Neuropeptides 2010)
Data last reviewed 2026-04-19 · Methodology →
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