⚖ Head-to-Head · Dual vs Triple Agonist

Tirzepatide vs Cagrilintide

Mechanism, half-life, dosing & research status compared side-by-side.

Tirzepatide
Metabolic / Dual Incretin Agonist
Approved (T2D 2022, obesity 2023)
GLP-1 AgonistGIP AgonistFDA ApprovedWeight ManagementMetabolic
Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly. By simultaneously activating both incretin receptors, t…
Full Tirzepatide profile →
Cagrilintide
Metabolic / Amylin Analog
Phase 3 (obesity); not yet approved
Amylin AnalogWeight ManagementMetabolicPhase 3Combination Therapy
Cagrilintide is a long-acting amylin analog developed by Novo Nordisk that acts on amylin receptors (calcitonin receptor/RAMP complex) in the hypothalamus and brainstem to regulate food intake and body weight. As a compl…
Full Cagrilintide profile →
Technical Specs Comparison
MetricTirzepatideCagrilintide
Research Status FDA Approved Phase 3 Clinical Trials
Molecular Weight 4813.47 Da ~4.1 kDa
Half-Life ~120 hours (5 days) ~7 days
Peak Time 8-72 hours post-injection 72-96 hours post-injection
Typical Dose 2.5-15 mg/week 0.3-4.5 mg/week
Frequency Once weekly Once weekly
Route Subcutaneous injection Subcutaneous injection
Amino Acids 39 37
WADA Status Not listed Not listed
FDA Status Approved (T2D 2022, obesity 2023) Phase 3 (obesity); not yet approved
Stack Compatibility & Key Differences
Tirzepatide has FDA approval; Cagrilintide is research-only.
PK Plotter
Visualize Tirzepatide plasma levels → Plot →
Frequently Asked Questions
What is the difference between Tirzepatide and Cagrilintide?
Tirzepatide: Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly. By simultaneously activating both incretin receptors, t… Cagrilintide: Cagrilintide is a long-acting amylin analog developed by Novo Nordisk that acts on amylin receptors (calcitonin receptor/RAMP complex) in the hypothalamus and brainstem to regulate food intake and body weight. As a compl…
Can you stack Tirzepatide and Cagrilintide?
Tirzepatide has FDA approval; Cagrilintide is research-only.
Which has a longer half-life, Tirzepatide or Cagrilintide?
Tirzepatide half-life: ~120 hours (5 days). Cagrilintide half-life: ~7 days.
✓
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-24.
● Peer-reviewed sources ● Audit timestamp: 2026-06-24 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Tirzepatide profile · Cagrilintide profile · All comparisons
Ready to calculate your exact draw volume?
Enter your vial size and BAC water to get precise IU markings for any dose.
Calculate Tirzepatide dose → Calculate Cagrilintide dose →