Metabolic & Weight

Tirzepatide Dosing & Reconstitution Calculator

Dual GIP and GLP-1 receptor agonist used for type 2 diabetes and weight loss.

TL;DR — Tirzepatide is a metabolic & weight peptide with a typical starting dose of 2.5 mg. For a 15 mg vial, add 1 mL bacteriostatic water to yield 15 mg/mL.
2.5 mg
Start Dose
15 mg
Vial
1 mL
BAC Water
15
mg/mL
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Frequently Asked
How do I reconstitute Tirzepatide?
Add 1 mL of bacteriostatic water to a 15 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 15 mg/mL.
What is the recommended dose of Tirzepatide?
A typical research dose is 2.5 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Tirzepatide vial?
A 15 mg vial reconstituted with 1 mL BAC water yields approximately 6 doses at 2.5 mg each.
Peptide Intelligence
What is the half-life of Tirzepatide?
Tirzepatide has a half-life of approximately 5 days, enabling once-weekly subcutaneous injection. Its dual GIP/GLP-1 activity provides complementary mechanisms for glycemic control and weight reduction.
What injection sites are suitable for Tirzepatide?
Administer subcutaneously in the abdomen, thigh, or upper arm. Rotate injection sites with each dose to minimize local tissue reactions and lipohypertrophy over time.
How long before Tirzepatide effects become noticeable?
Appetite reduction is often reported within the first 1–2 weeks. Measurable weight changes are typically observed by week 4. Peak efficacy at maximum tolerated dose generally emerges after 3–6 months of titration.
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Primary Sources
SURMOUNT-1 (NEJM 2022) SURPASS-2 (NEJM 2021) ClinicalTrials NCT04657003
Data last reviewed 2026-04-19 · Methodology →
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