Protocol
Longevity and Anti-Aging
Epithalon Longevity Protocol [2026]
Telomerase activation and pineal regulation using the synthetic tetrapeptide Epithalon (Epitalon).
Compounds
Epithalon
Dose: 5 mg
Freq: Once daily for 10 days
Recon: 10mg + 2mL BAC
Conc: 5 mg/mL
Draw: 20 units (U-100)
Calculate Epithalon dose
Protocol Phases
Primary Cycle
10 consecutive days
5 mg to 10 mg subcutaneous or intravenous daily for 10 days. Most research protocols use 5 mg/day for 10 days. IV administration is reported to produce stronger effects but SubQ is more practical.
Rest
6 months
No dosing. Allow telomere and pineal effects to consolidate.
Annual Repeat
Once or twice per year
Many longevity research protocols run 1 to 2 cycles per year. Some run 3 cycles in year 1 then maintenance once annually.
FAQ
What does Epithalon do?
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland protein epithalamin. It stimulates telomerase, the enzyme that extends telomeres, and regulates circadian rhythm and melatonin production through pineal gland normalization. It is researched for longevity and anti-aging applications.
Why is Epithalon dosed in a 10-day cycle rather than daily long-term?
The 10-day intensive cycle mimics the protocol used in the original Russian research by Khavinson et al. Epithalon appears to produce sustained downstream effects (particularly telomerase activation) that outlast the dosing period, making brief intensive cycles more appropriate than continuous daily use.
Can Epithalon be stacked with other longevity peptides?
Yes. Common stacks include Epithalon plus NAD+ precursors, Epithalon plus GHK-Cu (skin and longevity overlap), and Epithalon plus Thymalin (another Khavinson peptide). These are typically run sequentially, not simultaneously, to assess individual responses.
Is Epithalon the same as Epitalon?
Yes. Epithalon and Epitalon are the same tetrapeptide, Ala-Glu-Asp-Gly. The two spellings come from different transliterations of the Russian name (Эпиталон). They refer to identical compounds.
Research Notes
- Use bacteriostatic water for reconstitution. Store refrigerated after reconstitution.
- The 10-day protocol is derived from the original Khavinson research. Some newer protocols extend to 14 days.
- Morning dosing is preferred to align with natural circadian and pineal rhythms.
Related Protocols
For research use only. Not medical advice.