Metabolic & Longevity

5-Amino-1MQ Dosing Calculator

Name: 5-Amino-1MQ Dosing Data
Creator: ASCEND
License: https://creativecommons.org/licenses/by/4.0/

5-Amino-1-methylquinolinium — an NNMT inhibitor and NAD+ amplifier. Oral compound, no reconstitution required. Typical research dose 50 mg daily.

TL;DR — 5-Amino-1MQ is an oral NNMT inhibitor that raises intracellular NAD+ levels. Standard research dose is 50 mg daily. No reconstitution — taken orally as a capsule.

⚠ Note — ⚠ Oral compound — no reconstitution or injection required.

50 mg

Start Dose

50 mg

Vial Size

Oral

Route

—

Reconst.

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Frequently Asked

What is 5-Amino-1MQ?

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a cell-permeable NNMT inhibitor. NNMT (Nicotinamide N-methyltransferase) consumes S-adenosylmethionine and NAD+ precursors; blocking it raises intracellular NAD+ and SAM levels, supporting metabolic function.

How is 5-Amino-1MQ dosed?

Research protocols typically use 50 mg once daily, orally, with or without food. Some protocols use 25 mg twice daily. It is an oral compound and does not require reconstitution or injection.

Does 5-Amino-1MQ require a syringe?

No. Unlike most peptides on ASCEND, 5-Amino-1MQ is taken orally as a capsule or powder. The calculator displays dose guidance only — no syringe draw calculation applies.

How does 5-Amino-1MQ differ from NMN or NR?

NMN and NR are NAD+ precursors that supply raw material for NAD+ synthesis. 5-Amino-1MQ works upstream by blocking an enzyme that depletes NAD+ precursors, allowing the body to produce more NAD+ from existing resources.

Peptide Intelligence

What does NNMT inhibition do metabolically?

NNMT consumes 1-methylnicotinamide (a NAD+ metabolite) and SAM. Inhibiting NNMT preserves these metabolites, increases NAD+/NADH ratio, and has been associated with reduced adipogenesis and improved insulin sensitivity in rodent models.

Is 5-Amino-1MQ the same as 5-amino-1MQ iodide?

5-Amino-1MQ is frequently supplied as the iodide salt for research purposes. Iodide salt form has higher water solubility. Molecular weight: 158.18 g/mol (free base); 285.07 g/mol (iodide salt). Ensure your dose calculation accounts for the salt form if applicable.

Recommended Next Step

Stack with NAD+

NAD+ IV/subcutaneous protocols complement 5-Amino-1MQ by directly replenishing the coenzyme that NNMT inhibition helps preserve.

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About & Data Methodology

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