Cognitive
Semax Amidate Dosing & Reconstitution Calculator
Semax Amidate (N-Acetyl Semax Amide) — the most stable form of Semax, with both N-terminal acetylation and C-terminal amidation. Highest bioavailability. 300 mcg standard intranasal dose.
TL;DR — Semax Amidate combines N-acetylation and C-terminal amidation for maximum enzymatic stability among Semax variants. Standard vial: 5 mg in 5 mL BAC water (1,000 mcg/mL). Research dose: 300–600 mcg intranasally. Most potent of the three Semax variants.
300 mcg
Start Dose
5 mg
Vial
5 mL
BAC Water
1,000
mcg/mL
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Frequently Asked
How do I reconstitute Semax Amidate?
Add 5 mL of Bacteriostatic Water to a 5 mg Semax Amidate vial to yield 1,000 mcg/mL. For intranasal delivery, transfer to a nasal atomizer. Each 0.1 mL pump delivers 100 mcg. Store at 4°C and use within 30 days. The amidate form is more stable than standard Semax.
What makes Semax Amidate different from regular Semax?
Standard Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is susceptible to aminopeptidase degradation at the N-terminus and carboxypeptidase at the C-terminus. N-Acetyl Semax adds acetyl protection to the N-terminus. Semax Amidate adds C-terminal amidation. Semax Amidate combines both modifications for maximum stability and potency.
Is Semax Amidate stronger than N-Acetyl Semax?
Semax Amidate (N-Acetyl Semax Amide) is generally considered the most potent variant due to dual-end protection from enzymatic degradation. The C-terminal amide prevents carboxypeptidase cleavage, extending the active half-life beyond N-Acetyl Semax alone. Many researchers use 20–30% lower doses relative to standard Semax.
What route of administration is recommended for Semax Amidate?
Intranasal delivery is standard for all Semax variants. The olfactory-to-CNS transport route achieves CNS bioavailability of approximately 60–80%. Subcutaneous injection is also researched. Oral administration has minimal efficacy due to first-pass peptide degradation in the GI tract.
Peptide Intelligence
What is the molecular weight of Semax Amidate?
Semax Amidate (N-Acetyl-Met-Glu-His-Phe-Pro-Gly-Pro-NH2) has a molecular weight of approximately 898 Da. The standard Semax backbone is 813.94 Da; N-acetylation adds 42.04 Da and C-terminal amidation replaces the -OH with -NH2, reducing mass by ~0.98 Da.
How does Semax Amidate affect BDNF?
All Semax variants stimulate BDNF (brain-derived neurotrophic factor) expression in the hippocampus and frontal cortex via ACTH receptor activation. Semax Amidate achieves this at lower effective concentrations due to reduced enzymatic degradation. BDNF upregulation supports neuroplasticity, memory consolidation, and neuroprotection.
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Primary Sources
Agapova et al. — Semax BDNF (2007)
Dolotov et al. — ACTH Analogs (2006)
Data last reviewed 2026-04-20 · Methodology →
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