Cognitive
Synapsin Dosing & Reconstitution Calculator
Synapsin — a proprietary nootropic peptide blend combining GHK-Cu and Dihexa for synaptic density and cognitive enhancement research. Intranasal delivery. 300 mcg standard dose.
TL;DR — Synapsin is a compounded nootropic peptide formulation combining GHK-Cu and Dihexa. Delivered intranasally. Standard vial: 5 mg in 5 mL sterile saline (1,000 mcg/mL). Research dose: 300–600 mcg per administration. Store refrigerated.
⚠ Note — ⚠ Intranasal compound. Reconstitute in sterile preservative-free saline, not BAC water, for nasal delivery.
300 mcg
Start Dose
5 mg
Vial
5 mL
Sterile Saline
1,000
mcg/mL
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Frequently Asked
How is Synapsin reconstituted for intranasal use?
Synapsin is reconstituted in sterile preservative-free saline (not BAC water) for intranasal delivery. Add 5 mL saline to a 5 mg vial for 1,000 mcg/mL. Transfer to a nasal atomizer device. Each pump typically delivers 0.1 mL (100 mcg). Store at 4°C; use within 14 days.
What does Synapsin peptide do?
Synapsin is a compounded formulation typically combining GHK-Cu and Dihexa. GHK-Cu stimulates neurotrophin synthesis and synaptic plasticity via BDNF pathways. Dihexa (HGF receptor agonist) promotes synaptogenesis. The combination is researched for cognitive enhancement and neuroprotective applications.
What is the difference between Synapsin and Semax?
Semax is an ACTH-derived heptapeptide that increases BDNF and activates melanocortin receptors. Synapsin targets HGF/MET and BDNF/TrkB signaling through its Dihexa and GHK-Cu components. They work through distinct receptor systems and are sometimes stacked in nootropic research protocols.
Can Synapsin be injected subcutaneously?
Synapsin formulations are primarily designed for intranasal delivery to leverage olfactory transport to the CNS. Subcutaneous administration is researched but may reduce CNS bioavailability compared to the intranasal route. Use a nasal atomizer for intranasal protocols.
Peptide Intelligence
What is the mechanism of GHK-Cu in Synapsin?
GHK-Cu (Copper Tripeptide-1) in Synapsin activates gene transcription networks associated with neurotrophin synthesis, anti-oxidant defense, and synaptic remodeling. It upregulates BDNF and NGF expression and promotes dendritic arborization in preclinical models of neurodegeneration.
What is the mechanism of Dihexa in Synapsin?
Dihexa (N-hexanoic-Tyr-Ile-6-aminohexanoic amide) is a potent hepatocyte growth factor (HGF) receptor agonist. HGF/MET signaling promotes dendritic spine formation and long-term potentiation. Dihexa has demonstrated approximately 10^7 times greater potency than BDNF in promoting synaptogenesis in rodent models.
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Primary Sources
McCoy et al. — Dihexa Synaptogenesis (2013)
Pickart — GHK-Cu Neurotrophin (2008)
Data last reviewed 2026-04-20 · Methodology →
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