Add 1 mL of bacteriostatic water to a 50 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 50 mg/mL.
What is the recommended dose of AICAR?
A typical research dose is 50 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a AICAR vial?
A 50 mg vial reconstituted with 1 mL BAC water yields approximately 1 doses at 50 mg each.
Peptide Intelligence
What is AICAR and how does it activate AMPK?
AICAR is a cell-permeable nucleotide analog that is phosphorylated intracellularly to ZMP, an AMP mimetic. ZMP allosterically activates AMP-activated protein kinase (AMPK), the master cellular energy sensor, mimicking the metabolic effects of caloric restriction and exercise.
What metabolic effects does AICAR produce?
AICAR increases glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and GLUT4 translocation via AMPK. In rodent studies it improves endurance capacity without exercise. It also activates SIRT1, PGC-1a, and other longevity-associated pathways.
Is AICAR a peptide?
Technically, AICAR is a nucleotide analog rather than a traditional peptide. It is commonly included in peptide research compound databases due to its overlapping research context and subcutaneous administration route. It shares mechanism overlap with MOTS-C through shared AMPK activation pathways.