Longevity
FOXO4-DRI Dosing & Reconstitution Calculator
Senolytic peptide that selectively triggers apoptosis in senescent cells.
TL;DR - FOXO4-DRI is a longevity peptide with a typical starting dose of 2 mg. For a 10 mg vial, add 1 mL bacteriostatic water to yield 10 mg/mL.
2 mg
Start Dose
10 mg
Vial
1 mL
BAC Water
10
mg/mL
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Frequently Asked
How do I reconstitute FOXO4-DRI?
Add 1 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 10 mg/mL.
What is the recommended dose of FOXO4-DRI?
A typical research dose is 2 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a FOXO4-DRI vial?
A 10 mg vial reconstituted with 1 mL BAC water yields approximately 5 doses at 2 mg each.
How many IU is 2 mg of FOXO4-DRI on a syringe?
With a 10 mg vial reconstituted in 1 mL bacteriostatic water, the concentration is 10 mg/mL. For a 2 mg dose: Volume = 2 mg ÷ 10 mg/mL = 0.2 mL. Draw to the 20 line on a 100-unit insulin syringe. You can adjust these values in the ASCEND calculator for any vial size.
What does a FOXO4-DRI dosage calculator do?
A FOXO4-DRI dosage calculator converts your vial size and BAC water volume into an exact syringe draw in IU. Enter your vial strength (10 mg), reconstitution volume (1 mL), and target dose to get the precise line to draw on an insulin syringe.
What is the FOXO4-DRI reconstitution calculator formula?
Draw volume (mL) = Dose (mg) divided by Concentration (mg/mL). For a 10 mg vial with 1 mL BAC water: concentration = 10 mg/mL. For a 2 mg dose, the ASCEND calculator gives the exact IU line on your syringe instantly.
Peptide Intelligence
What is FOXO4-DRI and what makes it senolytic?
FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the interaction between FOXO4 and p53 inside senescent cells. Senescent cells overexpress FOXO4 to sequester p53 and block apoptosis. FOXO4-DRI releases p53 from this sequestration, restoring programmed cell death selectively in senescent cells.
What is the half-life of FOXO4-DRI?
FOXO4-DRI is composed of D-amino acids in a retro-inverso configuration, making it highly resistant to proteolytic degradation. Its plasma half-life is significantly longer than equivalent L-peptides. Reported research protocols use 3-day on/4-day off cycles, suggesting multi-day biological activity.
Has FOXO4-DRI shown rejuvenation effects in animal models?
The landmark 2017 Cell paper by Baar et al. showed FOXO4-DRI selectively killed senescent cells in aged mice, improving fitness (running endurance, grip strength), restoring fur density, and improving kidney function. No significant toxicity to non-senescent cells was observed at therapeutic doses.
Also Explore
Research Guides
Bacteriostatic Water Guide
What it is & why it matters for reconstitution
How Much BAC Water for FOXO4-DRI?
10 mg vial reconstitution recipe + concentration table
FOXO4-DRI on Insulin Syringe
2 mg draw on 30u / 50u / 100u syringes
Insulin Syringe Guide
Choosing the right gauge & volume for your draw
Multi-Lab Verification Standard
How ASCEND ensures dosing accuracy
Cite This Calculator