Anti-inflammatory tripeptide derived from alpha-MSH supporting gut and skin health.
TL;DR — KPV is a recovery & repair peptide with a typical starting dose of 500 µg. For a 10 mg vial, add 2 mL bacteriostatic water to yield 5000 µg/mL.
Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5000 µg/mL.
What is the recommended dose of KPV?
A typical research dose is 500 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a KPV vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 20 doses at 500 µg each.
Peptide Intelligence
What is the mechanism of KPV?
KPV (Lys-Pro-Val) is a C-terminal fragment of alpha-MSH that acts on melanocortin receptors (MC1R, MC3R) to suppress NF-kB signaling and reduce pro-inflammatory cytokine production. It is particularly active in gut epithelium and skin inflammatory models.
What conditions is KPV being researched for?
Primary research applications include inflammatory bowel disease, colitis, wound healing, and skin inflammatory conditions. KPV shows efficacy via both systemic injection and oral/rectal routes in rodent IBD models due to its stability in the gut environment.
What is the half-life of KPV?
KPV has a short half-life of approximately 30–60 minutes in plasma. However, its small size and resistance to some peptidases gives it surprising gut stability. Subcutaneous protocols typically use twice-daily administration.