Antimicrobial cathelicidin peptide supporting immune defense and wound healing.
TL;DR — LL-37 is a recovery & repair peptide with a typical starting dose of 100 µg. For a 5 mg vial, add 2 mL bacteriostatic water to yield 2500 µg/mL.
Add 2 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 2500 µg/mL.
What is the recommended dose of LL-37?
A typical research dose is 100 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a LL-37 vial?
A 5 mg vial reconstituted with 2 mL BAC water yields approximately 50 doses at 100 µg each.
Peptide Intelligence
What is the mechanism of LL-37?
LL-37 is a cathelicidin antimicrobial peptide that disrupts bacterial membranes, modulates TLR-signaling to reduce inflammatory overactivation, stimulates wound healing via EGFR and FPRL1 receptors, and promotes angiogenesis.
What is the half-life of LL-37?
LL-37 has a very short plasma half-life (minutes to a couple of hours) due to rapid proteolytic degradation. Research protocols frequently use subcutaneous injection, often daily or every other day, tailored to the indication.
Is LL-37 involved in immune modulation beyond antimicrobial action?
LL-37 is a potent immunomodulator. It reduces excessive pro-inflammatory signaling via TLR2/4 while promoting adaptive immunity. In autoimmune and wound contexts, its dual anti-inflammatory and pro-healing profile makes it an active research subject.