Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5 mg/mL.
What is the recommended dose of Melanotan I?
A typical research dose is 1 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Melanotan I vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 10 doses at 1 mg each.
Peptide Intelligence
What is the mechanism of Melanotan I for tanning?
Melanotan I (afamelanotide) selectively activates MC1R on melanocytes, stimulating eumelanin production. Unlike Melanotan II, it has very low affinity for MC3R and MC4R, minimizing sexual side effects and appetite changes while providing potent tanning activity.
What is the half-life of Melanotan I?
The standard peptide has a very short half-life (~22 minutes). The prodrug form (Scenesse) uses a biodegradable implant providing controlled release over approximately 2 months. Research-grade Melanotan I is administered subcutaneously daily or every other day.
What is Melanotan I (afamelanotide) approved for?
Afamelanotide (Scenesse) is approved in the EU and US for erythropoietic protoporphyria (EPP), a painful photodermatosis, where it provides photoprotection by increasing melanin density. This is the only approved clinical indication for melanocortin-based tanning peptides.