Cosmetic
Melanotan II Dosing & Reconstitution Calculator
Non-selective melanocortin agonist for tanning, libido, and appetite suppression.
TL;DR - Melanotan II is a cosmetic peptide with a typical starting dose of 250 µg. For a 10 mg vial, add 2 mL bacteriostatic water to yield 5000 µg/mL.
250 µg
Start Dose
10 mg
Vial
2 mL
BAC Water
5000
µg/mL
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250 µg start
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1 mg start
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Frequently Asked
How do I reconstitute Melanotan II?
Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5000 µg/mL.
What is the recommended dose of Melanotan II?
A typical research dose is 250 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Melanotan II vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 40 doses at 250 µg each.
How many IU is 250 µg of Melanotan II on a syringe?
With a 10 mg vial reconstituted in 2 mL bacteriostatic water, the concentration is 5000 µg/mL. For a 250 µg dose: Volume = 250 µg ÷ 5000 µg/mL = 0.05 mL. Draw to the 5 line on a 100-unit insulin syringe. You can adjust these values in the ASCEND calculator for any vial size.
What does a Melanotan II dosage calculator do?
A Melanotan II dosage calculator converts your vial size and BAC water volume into an exact syringe draw in IU. Enter your vial strength (10 mg), reconstitution volume (2 mL), and target dose to get the precise line to draw on an insulin syringe.
What is the Melanotan II reconstitution calculator formula?
Draw volume (mL) = Dose (µg) divided by Concentration (µg/mL). For a 10 mg vial with 2 mL BAC water: concentration = 5000 µg/mL. For a 250 µg dose, the ASCEND calculator gives the exact IU line on your syringe instantly.
Peptide Intelligence
How does Melanotan II differ from Melanotan I?
Melanotan II is a non-selective melanocortin agonist activating MC1R (tanning), MC3R (energy metabolism), MC4R (sexual arousal, appetite suppression), and MC5R (exocrine functions). This broader receptor activity produces tanning plus sexual effects, distinguishing it from the more selective Melanotan I.
What is the half-life of Melanotan II?
Melanotan II has a half-life of approximately 30–40 minutes after subcutaneous injection. Tanning effects build over days to weeks with repeated dosing as melanin synthesis accumulates. Sexual arousal effects are more acute, typically peaking 1–4 hours post-injection.
What side effects are commonly reported with Melanotan II?
Commonly reported effects include nausea (most common at higher doses or during titration), facial flushing, spontaneous erections in men, and fatigue. Stretch-mediated yawning is also frequently noted. Existing nevi may darken; new moles should be monitored by a dermatologist.
Also Explore
Research Guides
Bacteriostatic Water Guide
What it is & why it matters for reconstitution
How Much BAC Water for Melanotan II?
10 mg vial reconstitution recipe + concentration table
Melanotan II on Insulin Syringe
250 µg draw on 30u / 50u / 100u syringes
Melanotan II + PT-141 Stack
Pigmentation + libido (melanocortin axis)
Insulin Syringe Guide
Choosing the right gauge & volume for your draw
Multi-Lab Verification Standard
How ASCEND ensures dosing accuracy
Primary Sources
Melanocortin Agonist Review (Peptides 2007)
Data last reviewed 2026-06-03 · Methodology →
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