Non-selective melanocortin agonist for tanning, libido, and appetite suppression.
TL;DR — Melanotan II is a cosmetic peptide with a typical starting dose of 250 µg. For a 10 mg vial, add 2 mL bacteriostatic water to yield 5000 µg/mL.
Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5000 µg/mL.
What is the recommended dose of Melanotan II?
A typical research dose is 250 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Melanotan II vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 40 doses at 250 µg each.
Peptide Intelligence
How does Melanotan II differ from Melanotan I?
Melanotan II is a non-selective melanocortin agonist activating MC1R (tanning), MC3R (energy metabolism), MC4R (sexual arousal, appetite suppression), and MC5R (exocrine functions). This broader receptor activity produces tanning plus sexual effects, distinguishing it from the more selective Melanotan I.
What is the half-life of Melanotan II?
Melanotan II has a half-life of approximately 30–40 minutes after subcutaneous injection. Tanning effects build over days to weeks with repeated dosing as melanin synthesis accumulates. Sexual arousal effects are more acute, typically peaking 1–4 hours post-injection.
What side effects are commonly reported with Melanotan II?
Commonly reported effects include nausea (most common at higher doses or during titration), facial flushing, spontaneous erections in men, and fatigue. Stretch-mediated yawning is also frequently noted. Existing nevi may darken; new moles should be monitored by a dermatologist.