Cosmetic Peptide
Matrixyl Dosing & Reconstitution Calculator
Matrixyl (Palmitoyl-KTTKS / Pal-GHK) — a pro-collagen cosmetic peptide signaling fibroblasts to produce collagen I, III, and fibronectin. Topical 5% concentration standard.
TL;DR — Matrixyl is a palmitoylated peptide (Pal-KTTKS) that stimulates collagen and fibronectin synthesis. Standard research concentration is 5%. Vial: 100 mg in 2 mL — topical formulation standard.
⚠ Note — ⚠ Topical compound. Note: 5% concentration formulation standard.
5 mg
Start Dose
100 mg
Vial
2 mL
Vehicle
5%
Conc.
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Frequently Asked
What is Matrixyl?
Matrixyl is the trademarked name for Palmitoyl Pentapeptide-4 (Pal-KTTKS). It is a fragment of the procollagen type I sequence, palmitoylated to enhance skin penetration. It signals dermal fibroblasts to produce collagen I, III, IV, and fibronectin.
What concentration is used in research?
Standard cosmetic/research formulations use 3–5% Matrixyl by weight. ASCEND uses 5% as the default. It can be dissolved in water or propylene glycol and incorporated into serum or cream bases.
How many applications per vial?
A 100 mg vial dissolved in 2 mL vehicle yields 50 mg/mL (5% w/v). At 5 mg per application to a target area (~0.1 mL), this yields approximately 20 applications per vial.
Is Matrixyl the same as Matrixyl 3000?
Matrixyl 3000 is a combination of two peptides: Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tetrapeptide-7 (Pal-GQPR). Original Matrixyl contains only Pal-KTTKS. They work synergistically but are distinct compounds.
Peptide Intelligence
How does Matrixyl stimulate collagen?
The KTTKS sequence is derived from the CB3 fragment of procollagen type I. When applied topically, it binds to collagen synthesis receptors on fibroblasts, upregulating TGF-β signaling and increasing collagen I and III production. Palmitoylation enables transdermal delivery.
What is the difference between Matrixyl and GHK-Cu?
GHK-Cu is a copper tripeptide that stimulates collagen via wound-healing pathways (TGF-β, angiogenesis). Matrixyl (Pal-KTTKS) directly mimics the collagen precursor signal. Both increase collagen but through distinct mechanisms — they are complementary, not redundant.
Also Explore
Primary Sources
Robinson et al. — Pal-KTTKS Clinical (2005)
Lintner — Matrixyl Mechanism (2002)
Data last reviewed 2026-04-20 · Methodology →
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