Cosmetic Peptide

Palmitoyl Pentapeptide Dosing & Reconstitution Calculator

Name: Palmitoyl Pentapeptide Dosing Data
Creator: ASCEND
License: https://creativecommons.org/licenses/by/4.0/

Palmitoyl Pentapeptide (Pal-KTTKS / Palmitoyl Pentapeptide-3) — a pro-collagen signaling peptide for cosmetic research. 5 mg vial reconstituted in 2 mL.

TL;DR — Palmitoyl Pentapeptide (Pal-KTTKS) is a collagen-stimulating cosmetic peptide. Standard vial: 5 mg in 2 mL BAC water (2500 µg/mL). Typical dose: 1 mg. Often combined with GHK-Cu or Leuphasyl.

1 mg

Start Dose

5 mg

Vial

2 mL

BAC Water

2500

µg/mL

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This Peptide

Palmitoyl Pentapeptide

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Frequently Asked

How do I reconstitute Palmitoyl Pentapeptide?

Add 2 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the glass wall. Swirl gently. This yields 2500 µg/mL (2.5 mg/mL). Store at 4°C and use within 14 days.

What is Palmitoyl Pentapeptide used for?

Palmitoyl Pentapeptide (Pal-KTTKS) is studied for its ability to stimulate collagen I, III, and fibronectin synthesis in dermal fibroblasts. It is used in cosmetic research for anti-aging and skin regeneration protocols, often in combination with GHK-Cu or Matrixyl.

Is Palmitoyl Pentapeptide the same as Matrixyl?

Matrixyl is the trademarked product name for Palmitoyl Pentapeptide-4 (Pal-KTTKS). They refer to the same molecular compound. "Palmitoyl Pentapeptide-3" is an older nomenclature for the same peptide. ASCEND lists both for search completeness.

How many doses per vial?

A 5 mg vial in 2 mL BAC water yields 5 doses at 1 mg each (0.4 mL draw on a 100-IU syringe), or 10 doses at 0.5 mg. Use ASCEND to calculate exact draw volume for your dose.

Peptide Intelligence

What is the mechanism of Pal-KTTKS?

The KTTKS sequence (Lys-Thr-Thr-Lys-Ser) is derived from the CB3 region of type I procollagen. It acts as a matrikine — a fragment of the extracellular matrix that signals for its own resynthesis. Palmitoylation of the N-terminus enables transdermal delivery by increasing lipophilicity.

How is Palmitoyl Pentapeptide different from Palmitoyl Tripeptide-1?

Palmitoyl Tripeptide-1 (Pal-GHK) is a shorter peptide derived from collagen I that stimulates collagen and elastin via TGF-β. Palmitoyl Pentapeptide (Pal-KTTKS) is longer and acts directly on procollagen feedback. Together they form Matrixyl 3000.

Recommended Next Step

Also See: Matrixyl

Matrixyl is Palmitoyl Pentapeptide-4 under a trade name — same compound, often labeled differently across suppliers.

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