Cosmetic Peptide

Leuphasyl Dosing & Reconstitution Calculator

Name: Leuphasyl Dosing Data
Creator: ASCEND
License: https://creativecommons.org/licenses/by/4.0/

Leuphasyl (Tyr-D-Ala-Gly-Phe-Leu) — a synthetic opioid-related pentapeptide that relaxes facial muscle contractions. Cosmetic peptide research. 5 mg vial, 1 mg dose.

TL;DR — Leuphasyl is a synthetic enkephalin analogue that reduces acetylcholine release at neuromuscular junctions. Standard vial is 5 mg in 2 mL BAC water (2500 µg/mL). Typical dose: 1 mg.

1 mg

Start Dose

5 mg

Vial

2 mL

BAC Water

2500

µg/mL

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Frequently Asked

How do I reconstitute Leuphasyl?

Add 2 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the glass wall. Swirl gently — never shake. This yields 2500 µg/mL.

What is Leuphasyl used for in research?

Leuphasyl is studied as an anti-wrinkle peptide. It mimics enkephalin to inhibit acetylcholine release at the neuromuscular junction, reducing muscle contraction and thereby the appearance of expression lines. Often combined with Snap-8 (Argireline).

How many doses per Leuphasyl vial?

A 5 mg vial at 2500 µg/mL yields 5 doses at 1 mg each, or 10 doses at 0.5 mg each.

Is Leuphasyl injectable or topical?

In research, Leuphasyl is used both topically in serum formulations and as a subdermal injection. As a topical, it is typically formulated at 1–4% concentration. Injectable use follows standard reconstitution protocol.

Peptide Intelligence

How does Leuphasyl differ from Argireline?

Both act at the SNARE complex to reduce acetylcholine-triggered muscle contraction. Argireline (Snap-8) targets the SNAP-25 protein. Leuphasyl acts via opioid receptor modulation. Combining them (often 3% each) is claimed synergistic in cosmetic research.

What is the half-life of Leuphasyl?

As a pentapeptide, Leuphasyl has a short enzymatic half-life in plasma. Topical delivery is preferred for cosmetic applications. Injectable research uses BAC water reconstitution for subcutaneous or intradermal administration.

Recommended Next Step

Stack with Snap-8

Leuphasyl + Snap-8 (Argireline) is the most-researched anti-wrinkle peptide combination, acting on two distinct pathways of neuromuscular signaling.

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