Cognitive
Dihexa Dosing & Reconstitution Calculator
Potent HGF/c-Met modulator and oral nootropic for synaptic connectivity.
TL;DR - Dihexa is an oral cognitive compound typically dosed at 10 mg daily. No reconstitution is required.
10 mg
Start Dose
20 mg
Vial
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Frequently Asked
How do I reconstitute Dihexa?
Dihexa is taken orally; no reconstitution required.
What is the recommended dose of Dihexa?
A typical research dose is 10 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Dihexa vial?
A 20 mg vial reconstituted with 0 mL BAC water yields approximately 2 doses at 10 mg each.
Peptide Intelligence
What is the mechanism of Dihexa?
Dihexa is a small molecule HGF/c-Met system modulator that potentiates hepatocyte growth factor activity at the Met receptor. This drives synaptogenesis and dendritic spine formation in hippocampal and cortical neurons, with effects measurable at very low concentrations.
How potent is Dihexa compared to BDNF?
Dihexa has been reported to be approximately 7 orders of magnitude more potent than BDNF in driving synaptogenic activity in rodent models. Its oral bioavailability and CNS penetration distinguish it from peptidic neurotrophins that require intracranial delivery.
What is known about the half-life and duration of Dihexa?
Dihexa has better stability than peptide nootropics due to its small size and chemical modifications. While precise human pharmacokinetic data is limited, effects are reported to persist for days to weeks after acute dosing, suggesting a sustained downstream mechanism.
Also Explore
Primary Sources
HGF/c-Met Modulator (J Pharmacol Exp 2013)
Data last reviewed 2026-06-03 · Methodology →
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