Hormonal & Fertility

HMG Dosing & Reconstitution Calculator

Name: HMG Dosing Data
Creator: ASCEND
License: https://creativecommons.org/licenses/by/4.0/

Human Menopausal Gonadotropin — a combined FSH and LH preparation used in fertility and hormonal research. 75 IU standard vial reconstituted in 1 mL BAC water.

TL;DR — HMG (Human Menopausal Gonadotropin) contains both FSH and LH in a 1:1 ratio. Standard vial is 75 IU reconstituted in 1 mL bacteriostatic water. Typical research dose: 75 IU.

75 IU

Start Dose

75 IU

Vial

1 mL

BAC Water

IU/mL

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Frequently Asked

How do I reconstitute HMG?

Add 1 mL of bacteriostatic water to a 75 IU HMG vial, injecting slowly down the inside wall. Swirl gently — never shake. This yields a concentration of 75 IU/mL.

What is the difference between HMG and HCG?

HCG mimics LH only, stimulating Leydig cells to produce testosterone. HMG contains both FSH and LH, making it useful for protocols requiring both spermatogenesis support (FSH) and testosterone production (LH). In fertility research, they are often combined.

How many doses per HMG vial?

A 75 IU vial reconstituted in 1 mL yields 1 full dose at 75 IU, or 2 doses at 37.5 IU each. Higher-dose protocols (150 IU) require two vials per dose.

How many IU is 75 IU of HMG on a syringe?

With a 75 IU vial in 1 mL BAC water, concentration is 75 IU/mL. For a 75 IU dose: draw to the 100 line on a 100-unit insulin syringe (1.0 mL full draw). Use ASCEND calculator to adjust for custom volumes.

Peptide Intelligence

What does FSH do vs LH in HMG?

FSH (follicle-stimulating hormone) in HMG stimulates Sertoli cells for spermatogenesis. LH (luteinizing hormone) stimulates Leydig cell testosterone production. The 1:1 FSH:LH ratio in standard HMG makes it a comprehensive gonadotropin for research requiring both axes.

How should HMG be stored after reconstitution?

Refrigerate at 2–8°C after reconstitution and use within 30 days. Do not freeze reconstituted HMG. Lyophilized vials are stable for 24+ months at −20°C. Protect from light.

Recommended Next Step

Compare with HCG

HCG is the most common LH-mimetic. Understanding HMG vs HCG differences is critical for fertility and hormonal research protocol design.

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