Hypothalamic neuropeptide stimulating GnRH release and reproductive hormone cascade.
TL;DR — Kisspeptin-10 is a sexual health peptide with a typical starting dose of 100 µg. For a 5 mg vial, add 1 mL bacteriostatic water to yield 5000 µg/mL.
Add 1 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5000 µg/mL.
What is the recommended dose of Kisspeptin-10?
A typical research dose is 100 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Kisspeptin-10 vial?
A 5 mg vial reconstituted with 1 mL BAC water yields approximately 50 doses at 100 µg each.
Peptide Intelligence
What is the mechanism of Kisspeptin-10?
Kisspeptin-10 activates the KISS1R/GPR54 receptor in the hypothalamus, triggering a pulsatile surge of GnRH. This cascade stimulates LH and FSH release from the pituitary, which then drives testosterone and estrogen production from the gonads.
What is the half-life of Kisspeptin-10?
Kisspeptin-10 has a very short plasma half-life of approximately 2–4 minutes due to rapid enzymatic cleavage. Despite this, a single injection produces a measurable LH pulse lasting 60–90 minutes. Research protocols use infrequent pulsatile dosing to mimic natural GnRH secretion rhythms.
What is Kisspeptin-10 used for in fertility research?
Kisspeptin-10 is researched as an alternative to hCG for triggering ovulation in IVF protocols, with potentially lower ovarian hyperstimulation syndrome (OHSS) risk. It has been studied in clinical trials to restore GnRH pulsatility in hypogonadotropic hypogonadism.