Sexual Health

Kisspeptin-10 Dosing & Reconstitution Calculator

Hypothalamic neuropeptide stimulating GnRH release and reproductive hormone cascade.

TL;DR - Kisspeptin-10 is a sexual health peptide with a typical starting dose of 100 µg. For a 5 mg vial, add 1 mL bacteriostatic water to yield 5000 µg/mL.
100 µg
Start Dose
5 mg
Vial
1 mL
BAC Water
5000
µg/mL
100 µg draw on a 100-unit insulin syringe
01020304050607080901002 IUascendpeptide.org
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Frequently Asked
How do I reconstitute Kisspeptin-10?
Add 1 mL of bacteriostatic water to a 5 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5000 µg/mL.
What is the recommended dose of Kisspeptin-10?
A typical research dose is 100 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a Kisspeptin-10 vial?
A 5 mg vial reconstituted with 1 mL BAC water yields approximately 50 doses at 100 µg each.
How many IU is 100 µg of Kisspeptin-10 on a syringe?
With a 5 mg vial reconstituted in 1 mL bacteriostatic water, the concentration is 5000 µg/mL. For a 100 µg dose: Volume = 100 µg ÷ 5000 µg/mL = 0.02 mL. Draw to the 2 line on a 100-unit insulin syringe. You can adjust these values in the ASCEND calculator for any vial size.
What does a Kisspeptin-10 dosage calculator do?
A Kisspeptin-10 dosage calculator converts your vial size and BAC water volume into an exact syringe draw in IU. Enter your vial strength (5 mg), reconstitution volume (1 mL), and target dose to get the precise line to draw on an insulin syringe.
What is the Kisspeptin-10 reconstitution calculator formula?
Draw volume (mL) = Dose (µg) divided by Concentration (µg/mL). For a 5 mg vial with 1 mL BAC water: concentration = 5000 µg/mL. For a 100 µg dose, the ASCEND calculator gives the exact IU line on your syringe instantly.
Peptide Intelligence
What is the mechanism of Kisspeptin-10?
Kisspeptin-10 activates the KISS1R/GPR54 receptor in the hypothalamus, triggering a pulsatile surge of GnRH. This cascade stimulates LH and FSH release from the pituitary, which then drives testosterone and estrogen production from the gonads.
What is the half-life of Kisspeptin-10?
Kisspeptin-10 has a very short plasma half-life of approximately 2–4 minutes due to rapid enzymatic cleavage. Despite this, a single injection produces a measurable LH pulse lasting 60–90 minutes. Research protocols use infrequent pulsatile dosing to mimic natural GnRH secretion rhythms.
What is Kisspeptin-10 used for in fertility research?
Kisspeptin-10 is researched as an alternative to hCG for triggering ovulation in IVF protocols, with potentially lower ovarian hyperstimulation syndrome (OHSS) risk. It has been studied in clinical trials to restore GnRH pulsatility in hypogonadotropic hypogonadism.
Primary Sources
GnRH Stimulation (NEJM 2005)
Data last reviewed 2026-06-03 · Methodology →
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