Add 2 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 5 mg/mL.
What is the recommended dose of PT-141?
A typical research dose is 2 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a PT-141 vial?
A 10 mg vial reconstituted with 2 mL BAC water yields approximately 5 doses at 2 mg each.
Peptide Intelligence
What is the mechanism of PT-141?
PT-141 activates melanocortin receptors MC3R and MC4R in the CNS hypothalamus to increase sexual arousal and motivation. Unlike PDE5 inhibitors, PT-141 acts centrally on desire and arousal pathways rather than peripherally on vascular blood flow.
What is the half-life of PT-141?
PT-141 has a half-life of approximately 2.7 hours. Effects typically begin within 45–60 minutes of subcutaneous injection and last 4–12 hours. The FDA-approved form (Vyleesi) is injected subcutaneously into the abdomen or thigh 45 minutes before anticipated activity.
What is PT-141 FDA-approved for?
PT-141 (Bremelanotide / Vyleesi) received FDA approval in 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women. It is the only approved centrally-acting sexual dysfunction treatment. Off-label research explores its use in men with erectile dysfunction and low libido.