Cognitive
N-Acetyl Selank Amidate Dosing & Reconstitution Calculator
N-Acetyl Selank Amidate — the dual-modified form of Selank with N-terminal acetylation and C-terminal amidation for enhanced enzymatic stability and CNS bioavailability. 250 mcg standard dose.
TL;DR — N-Acetyl Selank Amidate is the most metabolically stable form of Selank. Both termini are protected against enzymatic cleavage. Standard vial: 5 mg in 5 mL BAC water (1,000 mcg/mL). Research dose: 250–500 mcg intranasally. For Laboratory Research Use Only.
250 mcg
Start Dose
5 mg
Vial
5 mL
BAC Water
1,000
mcg/mL
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Frequently Asked
How do I reconstitute N-Acetyl Selank Amidate?
Add 5 mL of Bacteriostatic Water to a 5 mg vial to achieve 1,000 mcg/mL. For intranasal delivery, transfer to a nasal atomizer device. Each 0.1 mL pump delivers 100 mcg. The amidate form is stable for 30 days at 4°C — longer than standard Selank due to reduced enzymatic cleavage.
What is N-Acetyl Selank Amidate and how does it differ from Selank?
Standard Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is an anxiolytic heptapeptide analog of tuftsin. N-Acetyl Selank Amidate adds N-terminal acetylation and C-terminal amide protection. These modifications block aminopeptidase and carboxypeptidase attack, extending half-life and improving CNS penetration efficiency.
Is N-Acetyl Selank Amidate stronger than regular Selank?
Due to enhanced stability, N-Acetyl Selank Amidate achieves equivalent or greater receptor activation at lower effective concentrations. Researchers typically reduce doses by 20–30% relative to standard Selank while maintaining equivalent GABAergic and BDNF modulation effects.
What are the cognitive effects studied with N-Acetyl Selank Amidate?
N-Acetyl Selank Amidate research focuses on anxiolytic activity via GABA-A modulation, BDNF upregulation, and enkephalin system interaction. It is studied for anxiety reduction, cognitive enhancement under stress conditions, and neuroprotection. Selank was developed at the Russian Institute of Molecular Genetics as a tuftsin analog.
Peptide Intelligence
What is the molecular weight of N-Acetyl Selank Amidate?
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) has a molecular weight of 751.86 Da. N-Acetylation adds 42.04 Da; C-terminal amidation is a structural modification with negligible mass change (~-0.98 Da). N-Acetyl Selank Amidate has an approximate molecular weight of 892.94 Da.
Why does C-terminal amidation improve peptide stability?
The C-terminal carboxylate group (-COOH) is the primary substrate for carboxypeptidase enzymes in serum and tissue. Replacing it with an amide (-NH2) renders the C-terminus unrecognizable to these enzymes, preventing sequential C-to-N degradation. Combined with N-acetylation, this shields both termini from the two primary peptide degradation pathways.
Also Explore
Primary Sources
Semenova et al. — Selank Anxiolytic (2010)
Zozulya et al. — Selank Clinical (2014)
Data last reviewed 2026-04-20 · Methodology →
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