Add 1 mL of bacteriostatic water to a 1 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 1000 µg/mL.
What is the recommended dose of VIP?
A typical research dose is 50 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a VIP vial?
A 1 mg vial reconstituted with 1 mL BAC water yields approximately 20 doses at 50 µg each.
Peptide Intelligence
What is VIP and what systems does it regulate?
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide expressed throughout the CNS, gut, and immune system. It activates VPAC1 and VPAC2 receptors, producing bronchodilation, vasodilation, anti-inflammatory effects, and circadian rhythm modulation.
What is VIP's role in CIRS (Chronic Inflammatory Response Syndrome)?
In CIRS research, VIP is used to address blunted endogenous VIP production seen in biotoxin illness. Intranasal VIP administration in protocols developed by Dr. Shoemaker has shown normalization of inflammatory markers and symptom reduction in some research subjects.
What is the half-life of VIP?
VIP has a very short plasma half-life of approximately 2 minutes due to rapid enzymatic cleavage by DPP-IV and other peptidases. Intranasal administration is preferred in CIRS protocols to provide direct CNS and nasal mucosa delivery while minimizing systemic degradation.