Cognitive
VIP Dosing & Reconstitution Calculator
Vasoactive intestinal peptide for CIRS, neuroinflammation, and gut-brain axis.
TL;DR - VIP is a cognitive peptide with a typical starting dose of 50 µg. For a 1 mg vial, add 1 mL bacteriostatic water to yield 1000 µg/mL.
50 µg
Start Dose
1 mg
Vial
1 mL
BAC Water
1000
µg/mL
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Frequently Asked
How do I reconstitute VIP?
Add 1 mL of bacteriostatic water to a 1 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 1000 µg/mL.
What is the recommended dose of VIP?
A typical research dose is 50 µg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a VIP vial?
A 1 mg vial reconstituted with 1 mL BAC water yields approximately 20 doses at 50 µg each.
How many IU is 50 µg of VIP on a syringe?
With a 1 mg vial reconstituted in 1 mL bacteriostatic water, the concentration is 1000 µg/mL. For a 50 µg dose: Volume = 50 µg ÷ 1000 µg/mL = 0.05 mL. Draw to the 5 line on a 100-unit insulin syringe. You can adjust these values in the ASCEND calculator for any vial size.
What does a VIP dosage calculator do?
A VIP dosage calculator converts your vial size and BAC water volume into an exact syringe draw in IU. Enter your vial strength (1 mg), reconstitution volume (1 mL), and target dose to get the precise line to draw on an insulin syringe.
What is the VIP reconstitution calculator formula?
Draw volume (mL) = Dose (µg) divided by Concentration (µg/mL). For a 1 mg vial with 1 mL BAC water: concentration = 1000 µg/mL. For a 50 µg dose, the ASCEND calculator gives the exact IU line on your syringe instantly.
Peptide Intelligence
What is VIP and what systems does it regulate?
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide expressed throughout the CNS, gut, and immune system. It activates VPAC1 and VPAC2 receptors, producing bronchodilation, vasodilation, anti-inflammatory effects, and circadian rhythm modulation.
What is VIP's role in CIRS (Chronic Inflammatory Response Syndrome)?
In CIRS research, VIP is used to address blunted endogenous VIP production seen in biotoxin illness. Intranasal VIP administration in protocols developed by Dr. Shoemaker has shown normalization of inflammatory markers and symptom reduction in some research subjects.
What is the half-life of VIP?
VIP has a very short plasma half-life of approximately 2 minutes due to rapid enzymatic cleavage by DPP-IV and other peptidases. Intranasal administration is preferred in CIRS protocols to provide direct CNS and nasal mucosa delivery while minimizing systemic degradation.
Also Explore
Research Guides
Bacteriostatic Water Guide
What it is & why it matters for reconstitution
How Much BAC Water for VIP?
1 mg vial reconstitution recipe + concentration table
VIP on Insulin Syringe
50 µg draw on 30u / 50u / 100u syringes
Insulin Syringe Guide
Choosing the right gauge & volume for your draw
Multi-Lab Verification Standard
How ASCEND ensures dosing accuracy
Cite This Calculator